Hereditary Cancer Screening


Hereditary Cancer testing analyzes mutations in a patient’s DNA known to be associated with an increased risk of certain types of hereditary cancer. We provide a comprehensive report indicating a patient’s potential susceptibility to various hereditary cancers. This testing uses the latest next generation sequencing technology to analyze patient samples in a rapid and accurate fashion.

Patients could be at an increased risk for hereditary cancer if they or their family has a history of any of the following:

• An individual having more than one (1) cancer

• An individual who has multiple close family members under the age of fifty (50) with a cancer diagnosis

• An individual having three (3) or more close family members with different types of cancer

• An individual having a family that has previously had cancer genetic testing and mutations were identified

This information helps guide a clinician’s route of personalized therapy dependent on the specific genomic mutation and associated cancer. Currently, we offer the analysis of 37 genes covering 18 different cancers as shown below:

Gene(s): Associated Cancer(s)/Tumor(s)

APC: Colorectal, central nervous system, thyroid, liver, duodenal, pancreatic

ATM: Breast, pancreatic

NBN: Breast, prostate, possibly ovarian

BRCA1, BRCA2: Breast, ovarian, prostate, pancreatic, male breast

BRIP1, RAD51C, RAD51D: Breast, ovarian

BMPR1A, SMAD4: Stomach, colorectal, pancreatic

CDH1: Breast, colorectal, gastric

CDK4: Melanoma

CDKN2A: Melanoma, pancreatic

CHEK2: Breast, colorectal

FH: Kidney, Leiomyomas

FLCN: Kidney

MAX: Pheochromocytoma

MLH1, MSH2, MSH6, PMS2,EPCAM: Ovarian, Colorectal, Uterine, Stomach, Small Bowel, Hepatobiliary, Brain,

Pancreatic, Sebaceous, Urinary Tract

MUTYH: Breast, Colorectal

NF1: Optic Glioma, Gastrointestinal Stromal Tumor, Paraganglioma/Pheochromocytoma, Neurofibromas, Breast, Central Nervous System

PALB2: Breast, Pancreatic

PTEN: Breast, Uterine, Thyroid, Colorectal, Kidney

RET: Thyroid (medullary), Pheochromocytoma

SDHAF2, SDHB, SDHC, SDHD: Kidney, Paraganglioma/Pheochromocytoma, Gastrointestinal Stromal Tumor

TSC1, TSC2: Kidney, cardiac Rhabdomyomas, Central Nervous System

STK11: Colorectal, small bowel, pancreatic, breast, ovarian

TMEM127: Paraganglioma/Pheochromocytoma

TP53: Brain, leukemia, Breast, Sarcoma, Adrenocortical, Gastrointestinal, Genitourinary

VHL: Kidney, pheochromocytoma, Central Nervous System

South East Office

420 20th Street N,

Suite 2200,

Birmingham, AL 35203

Phone. 205-379-1147

North East Office

2009 Mackenzie Way,

Suite 100,

Cranberry Township, PA 16066

Phone. 724-720-9302

Consulting Partnership Opportunities

Crosby Taylor
Business Development
Phone Number: 205-379-1147